Board of Directors

  • David Sanford

    Founder, CEO, and Board Member
    Hypothesis Fund

    David founded the Hypothesis Fund in 2022 to support breakthrough research that increases our adaptability against systemic risks to the health of humans and the planet.

    Prior to launching the Hypothesis Fund, David was Chief of Staff in the Office of Reid Hoffman, responsible for managing a broad portfolio of philanthropic, civic, business, and intellectual initiatives.

    He has served as a Board Observer at Change.org and on numerous nonprofit and company advisory boards.

    David has pioneered community building both in the digital and physical realms. As an early employee at LinkedIn he created one of the first mechanisms for supporting philanthropic causes via social networks: LinkedIn for Good. After building early communities on the Web, David took this practice back to the physical world, opening and operating a restaurant designed to cultivate community through shared meals.

    Earlier in his career, as a research assistant in the Orthopaedic Sciences Laboratory at the University of Washington, David developed a novel platform for studying bone loss, which remains a core component of the lab’s research now two decades later.

    David earned his B.A. degree with Honors from Stanford University.

  • Cecilia Conrad, Ph.D.

    CEO, Lever for Change;
    Managing Director, John D. and Catherine T. MacArthur Foundation

    Lever for Change is a new nonprofit affiliate of the MacArthur Foundation whose mission is to unlock philanthropic capital and accelerate solutions to the world’s biggest social challenges. In addition to her role at Lever for Change, Dr. Conrad oversees the MacArthur Fellows program and MacArthur’s 100&Change, the Foundation’s competition for a single $100 million grant to help solve a critical problem of our time.

    Before joining the Foundation in January 2013, Conrad had a distinguished career as both a professor and an administrator at Pomona College in Claremont, CA. She held the Stedman Sumner Chair in Economics and is currently an emerita professor of economics. She served as Associate Dean of the College (2004-2007), as Vice President for Academic Affairs and Dean of the College (2009-2012), and as Acting President (Fall 2012). From 2007-2009, she was interim Vice President and Dean of the Faculty at Scripps College.

    Before joining the faculty at Pomona College, Conrad served on the faculties of Barnard College and Duke University. She was also an economist at the Federal Trade Commission and a visiting scholar at The Joint Center for Political and Economic Studies.

    Dr. Conrad is a member of the Board of Trustees of Bryn Mawr College, the Poetry Foundation, the National Academy of Social Insurance, IES, and the Sylvia Bozeman and Rhonda Hughes EDGE Foundation. She is a Trustee Emerita of Muhlenberg College.

    She has received numerous recognitions for her scholarship and leadership, including California’s Carnegie Professor of the Year (2002), National Urban League’s Women of Power Award (2008), and the National Economic Association’s Samuel Z. Westerfield Award (2018). She has honorary doctorates from Claremont Graduate University and the University of Massachusetts Dartmouth. Dr. Conrad received her B.A. degree from Wellesley College and her Ph.D. in economics from Stanford University.

  • Shirley Tilghman, Ph.D.

    President Emerita and Professor of Molecular Biology and Public Affairs, Princeton University

    Shirley M. Tilghman was elected Princeton University’s 19th president on May 5, 2001 after serving on the Princeton faculty for 15 years.  Upon the completion of her term in June of 2013, she returned to the faculty.

    During her scientific career as a mammalian developmental geneticist, she studied the way in which genes are organized in the genome and regulated during early development, and was one of the founding members of the National Advisory Council of the Human Genome Project for the National Institutes of Health. 

    Dr. Tilghman is an Officer of the Order of Canada, the recipient of a Lifetime Achievement Award from the Society for Developmental Biology, the Genetics Society of America Medal, and the L’Oreal-UNESCO Award for Women in Science. She is a member of the American Philosophical Society, the National Academy of Sciences, the National Academy of Medicine and The Royal Society of London.  She serves on the boards of the Simons Foundation, the Broad Institute of MIT and Harvard, the Institute for Advanced Study, and the American Academy of Arts and Sciences.  

  • Jay Shendure, M.D., Ph.D.

    Scientific Director of the Seattle Hub for Synthetic Biology, Professor of Genome Sciences, University of Washington School of Medicine

    Jay Shendure is an Investigator of the Howard Hughes Medical Institute, a Professor of Genome Sciences at the University of Washington, and Scientific Director of the Seattle Hub for Synthetic Biology (Allen-CZI-UW), the Allen Discovery Center for Cell Lineage Tracing, and the Brotman Baty Institute for Precision Medicine.

    His 2005 doctoral thesis with George Church included one of the first successful reductions to practice of next-generation DNA sequencing.

    Dr. Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays, saturation genome editing; combinatorial single cell molecular technologies; and genome editing-based molecular recording technologies.

    Dr. Shendure is the recipient of the Curt Stern Award from the American Society of Human Genetics (2012), the Richard Lounsbery Award from the National Academy of Sciences (2019) and the Mendel Award from the European Society of Human Genetics (2022). He is an elected member of the American Association for the Advancement of Science and the National Academy of Sciences. He serves or previously served as an advisor to the NIH Director, the US Precision Medicine Initiative, National Human Genome Research Institute, Chan Zuckerberg Initiative, Gladstone Institute, New York Genome Center and Allen Institute. He received his MD and PhD degrees from Harvard Medical School in 2007.

  • Reid Hoffman

    Co-Founder of LinkedIn and Inflection AI;
    Partner at Greylock

    An accomplished entrepreneur, executive, and investor, Reid Hoffman has played an integral role in building many of today’s leading consumer technology businesses. In 2003 he co-founded LinkedIn, the world’s largest professional networking service. In 2009 he joined Greylock. In 2022, he co-founded Inflection AI. He currently serves on the boards of Aurora, Coda, Convoy, Entrepreneur First, Joby, Microsoft, Nauto, Neeva, and a few early stage companies still in stealth. In addition to the Hypothesis Fund, he serves on a number of not-for-profit boards, including Kiva, Endeavor, CZ Biohub, New America, Berggruen Institute, Opportunity@Work, the Stanford Institute for Human-Centered AI, and the MacArthur Foundation’s Lever for Change. He is the host of Masters of Scale, an original podcast series and the first American media program to commit to a 50-50 gender balance for featured guests. He is the co-author of four best-selling books: The Start-Up of You, The Alliance, Blitzscaling, and Masters of Scale. He is an Aspen Institute Crown Fellow, a Marshall Scholar at Oxford, and a graduate of Stanford University.

  • Board Member Emeritus, John O. Dabiri, Ph.D.

Scientific Advisory Board

 

Operations

  • Pajau Vangay Portrait

    Pajau Vangay, Ph.D.

    Sr. Director, Scientific Network

    Pajau Vangay received her Ph.D. in Computational Biology from the University of Minnesota, where she worked in the research lab of Dr. Dan Knights. Her graduate research focused on the impact of migration on the human gut microbiome and obesity development in refugee communities in the US. She also has a M.S. degree in Food Microbiology from Cornell University, and a B.S. in Computer Science from the Colorado School of Mines.

    After completing her Ph.D., she joined the California Council on Science and Technology Science and Technology Policy Fellowship program as a policy committee consultant and legislative aide in the California Legislature. Prior to her current role at the Hypothesis Fund, she was based at Lawrence Berkeley National Laboratory, where she was the Scientific Community Manager for the National Microbiome Data Collaborative and partnered with scientific communities to champion open science and data stewardship practices. As Sr. Director, Scientific Network at the Hypothesis Fund, she supports and empowers our diverse network of scientists in identifying and pursuing high-risk, high-reward projects.

  • David Sanford

    Founder & CEO

    David founded the Hypothesis Fund in 2022 to support breakthrough research that increases our adaptability against systemic risks to the health of humans and the planet.

    Prior to launching the Hypothesis Fund, David was Chief of Staff in the Office of Reid Hoffman, responsible for managing a broad portfolio of philanthropic, civic, business, and intellectual initiatives.

    He has served as a Board Observer at Change.org and on numerous nonprofit and company advisory boards.

    David has pioneered community building both in the digital and physical realms. As an early employee at LinkedIn he created one of the first mechanisms for supporting philanthropic causes via social networks: LinkedIn for Good. After building early communities on the Web, David took this practice back to the physical world, opening and operating a restaurant designed to cultivate community through shared meals.

    Earlier in his career, as a research assistant in the Orthopaedic Sciences Laboratory at the University of Washington, David developed a novel platform for studying bone loss, which remains a core component of the lab’s research now two decades later.

    David earned his B.A. degree with Honors from Stanford University.